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Prof. Yukui Zhang

Member of Chinese Academy of Sciences


Prof. Yukui Zhang was born in 1942, Baoding, China. He is a member of Chinese Academy of Sciences, professor of Dalian Institute of Chemical Physics, Chinese Academy of Sciences and Ph. D. supervisor. After graduated from Department of Chemistry, Nankai University in 1965, he has been working in Dalian Institute of Chemical Physics until now. He was the Deputy Director of Dalian Institute of Chemical Physics and Director of National Chromatographic R. & A. Center as well as senior visiting scientist of Eberhard-Karls-Universitaet Tuebingen, Germany and United States Environmental Protection Agency. He is Expert team member of National High-tech R&D Program "Proteomics Study Project", Consulting expert for National Natural Science Foundation of China on chemistry, Vice President of China Association for Instrument Analysis, the president of Chinese Chromatography Society, and international editor of Journal of Chromatography A, Talanta and Anal. Chim. Acta.  

His research is focused on the fundamental study and development of new techniques and methods of chromatography and made tremendous contribution to the development of chromatographic science of China. In the area of fundamental research, he investigated the retention behavior of solutes under various modes of chromatography using methods of statistical thermodynamics, induced theoretical expression describing the effect of mobile phase composition on the chromatographic retention with clear physical meaning, illustrated the molecular structural factors that affect the separation behavior in the chromatographic process. Based on these researches, he established systematic methodology for thermodynamic study of chromatography and theoretical bases for the development of expert systems for chromatography. Based on the principle of mass balance, he built the mass balance model of solute migration in the whole chromatographic system including the influence of extra-column effect, studied the higher-order statistical moments of the elution profile of chromatography, theoretically illustrated the dynamic factors that affect the broadening and symmetry of chromatographic peaks, verified the quantitative relationship between retention time and half peak width. He applied the Gaussian convolution model to fit the chromatographic elution profile, discovered the quantitative relationship between model parameters and operation conditions of chromatography and solved several difficult problems such as storage of chromatograms and quantitative deconvolution of overlapped peaks. During the establishment of expert system for liquid chromatography, he proposed the concept of "knowledge base must be based on the combination of chromatographic theory and experience rules" for the first time to overcome the one-sideness of foreign researchers to consider only the experience rules. The knowledge base established according to this concept has been applied to the recommendation of columns systems of liquid chromatography and its correctness and reliability has been verified by many practical experiments. He established intelligent optimization strategy by combining serial optimization criteria and intelligent search method and applied it to the optimization of separation conditions for complex samples. In the theoretical study of capillary electrophoresis, he discovered the rules of the effect of operation conditions and molecular structure of solutes on the migration behavior of solutes in capillary zone electrophoresis. For the first time he carried research on the open tubular capillary electrochromatography with physically absorbed stationary phases.He developed several kinds of capillary electrochromatography columns including columns with mixed materials and monolithic polymer as stationary phases, investigated the separation mechanism and rules of on-column enrichment of solutes on different kinds of columns and achieved 17000 folds enrichment in capillary electrochromatography for basic samples.

 On the basis of thorough theoretical study, he put great emphasis on the completion of national commissions as well as application and development of instruments. In 1968 he undertook the project of The National Committee of Defense Industry of Science and Technology "air content analyzer for 09-II nuclear submarine". He prosposed four-column-four-detector back purge process, which can be used to simultaneously analyze the trace and normal components in the air and developed four types of radioactive ionization detector. The prototype of the analyzer was on-site tested on ship and conventional sumarine, and installed on the 09-II nuclear submarine for air analysis. For this he was awarded the prize of the science and technological achievement of CAS in 1978. In 1983, he undertook National Sixth Five-Year project of The State Science and Technology Commission and cooperated with other scientists to develop the prototype of Type 2003 intelligent high performance liquid chromatograph successfully. On this basis, he developed and commercialized the whole series of liquid chromatographic instruments including high pressure pump and UV Variable Wavelength detector. From 1978, he was in charge of the project of CAS "Development of k-1 high performance liquid chromatographic column based on absorption", developed and commercialized high performance liquid chromatographic column based on absorption with inner diameter ranging from 1 to 5 mm and was awarded the first prize of Scientific and Technological Achievements of Liaoning Province in 1979. In 1986, he was in charge of "863" project "development of radial chromatographic column for the separation and purification of biotechnology downstream target products", developed four kinds of ion-exchange membrane radial flow chromatographic columns, among which the weak cation-exchange column was developed for the first time. After that, several kinds of radial chromatographic columns including affinity membrane radial chromatographic columns, polymeric monolithic electrochromatographic columns and supramolecular linear polyacrylamide chromatographic column for no gel capillary electrophoresis were successively developed and several patents were applied. He also undertook the cooperation project between China and Us "monitoring of toxic pollutants in flue gases", propose the method of resolving the complex samples from fixed pollutants sources using gas chromatography assisted Fourier transform infrared spectroscopy, established the corresponding database for FT-IR subtraction quantification. The project was appraised, checked and accepted by State Environment Protection Administration. His work also obtained high opinions from the US experts. He applied microdialysis-HPLC, affinity chromatography and capillary electrophoresis to investigate the interaction between various pharmaceutical drugs and human serum proteins. For the first time he established the systematic method for the study of interactions between drugs and proteins; discussed the relationship between the pharmaceutical effect of drugs and drug-protein interaction-site as well as equilibrium constant between drugs and proteins.

     In recent years, following the trend of analytical chemistry and international front-edge and combining the requirement of national important application area, he kept a close eye on the interdisciplinary development of analytical science and life science. His main research area is high efficient separation and high sensitive detection of proteins with emphasis on the development of multi-dimensional liquid separation systems including multi-dimensional liquid chromatography, multi-dimensional capillary electrophoresis and coupling with mass spectrometry. He proposed the concept of developing platform for the separation and identification of proteins consisting of protein separation-online enzymatic digestion-peptide separation-Mass spectrometry identification and developed several kinds of in-situ enzymatic micro-reactors. In addition, in order to for the high efficient enrichment of trace components, he developed monolithic materials based immobilized metal affinity chromatographic stationary phases, capillary electrophoresis and capillary electrochromatography based technologies for the universal and selective enrichment of proteins. He has published more than 500 papers in domestic and international journals, 7 books including "Analytical Chemistry Manual (part VI)" and "Modern Methods for the Separation and Analysis of Biological Samples" and applied for more than 30 patents.

During the scientific research, he insisted on the people-oriented principle, accorded great importance to the cultivation of talents. He has supervised more than 20 Ph. D. students. Among them, some already became Ph. D. supervisors, some were awarded the support of "100-talents project" of CAS and some are working as core members of scientific research in instrumental companies. They play important roles in several areas such as the basic research of analytical science and application, development and commercialization of instruments. 

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